Programme

 

The Scheduled Programme is now available for download.

 

 

Sunday 11th September 2016 - Palazzo dei Priori, Sala dei Notari (map)

14.30-17.00

REGISTRATION

17.00-17.30

OPENING CEREMONY:
Girolamo Cirrincione – Chairman of the Scientific Committee
Gabriele Costantino   President of the Medicinal Chemistry Division
Violetta Cecchetti
 Co-Chair of the Organizing Committee
Benedetto Natalini 
– Co-Chair of the Organizing Committee

17.30-17.50

ChemMedChem 10th Anniversary Celebration - MedChem publishing its best – from Il Farmaco to ChemMedChem
Peter Goelitz  - Editor-in-chief Angewandte Chemie

 

17.50-18.20

Medicinal Chemistry Division of the Italian Chemical Society’s Awards

Rosella Ombrato, Angelini Research Center, S. Palomba, Rome, Italy
Fabrizio Carta, University of Florence
, Italy

Best Doctoral Thesis Awards

Sara Consalvi, University La Sapienza, Rome, Italy
Valeria FamigliniUniversity La Sapienza, Rome, Italy

18.20-18.50

Musajo Medal of the Medicinal Chemistry Division of the Italian Chemical Society

Recipient: Pier Giovanni Baraldi, University of Ferrara, Italy

18.50-19.50

Chair: Gabriele Costantino – President of the Medicinal Chemistry Division

 

OL: Engineering novel drugs. A long journey into the changing landscape of drug discovery
Roberto Pellicciari, TES Pharma, Perugia, Italy

20.00

Chiostro di San Lorenzo  (map)                                                                     WELCOME BUFFETChemMedChem  10th Anniversary Celebration

 

 

 

 

Monday 12th September 2016 – Hotel Giò

 

 

Auditorium

 

 

Chair: Daniele Donati

8.30-9.20

ChemMedChem 10th Anniversary PLPARP inhibitors for the treatment of human cancer

Alessia Montagnoli, Nerviano Medical Sciences S.r.l., Nerviano (MI), Italy

 

 

Auditorium

NMMC-1

 

Chairs: Girolamo Cirrincione and Daniele Donati

9.30-10.00

KN:  Fused nitrogen heterocycles as promising photosensitizing agents in the treatment of cancer
Paola Barraja
,
University of Palermo, Italy

10.00-10.20

OC:  New potent reversible inhibitors of Histone Lysine Demethylase (KDM1A/LSD1)
Paolo Vianello,
European Institute of Oncology (IEO), Milan, Italy

10.20-10.40

OC:  Protein-protein interaction studies to combat carcinomas. The drug walks to the target.
Maria Paola Costi,
University of  Modena - Reggio Emilia, Italy

10.40-11.00

COFFEE BREAK

11.00-11.20

OC:  A novel Cu(II) complex targeting TSPO: in vitro and in vivo antitumor potential and mechanistic insights
Valentina Gandin,
University of Padua, Italy

11.20-11.40

OC:  Novel insights on the pharmacological properties of juglone, plumbagin, and their semisynthetic derivatives
Francesco Epifano,
University of Chieti, Italy

11.40-12.00

OC:  Heparanase: insights into inhibition by roneparstat and discovery of novel inhibitors
Silvia Rivara,
University of Parma, Italy

 

 

Trumpet

NMMC-2

 

Chairs: Maurizio Recanatini and Gabriele Costantino

9.30-10.00

KN:  New trends in exploring ligand-GPCR recognition pathways
Stefano Moro
,
University of Padua, Italy

10.00-10.20

OC:  Novel, selective and developable dopamine D3 antagonists with modified “amino” region
Fabrizio Micheli,
Aptuit, Verona, Italy

10.20-10.40

OC:  Molecular dynamics in drug discovery: targets of drug addiction as a case study
Maria Rosaria Ferraro,
IIT, Genoa, Italy

10.40-11.00

COFFEE BREAK

11.00-11.20

OC:  The double life of UNIFI nootropics
Maria Novella Romanelli, University of Florence, Italy

11.20-11.40

OC:  Development of ureidopropanamide derivatives as formyl peptide receptor 2 (ALX/FPR2) agonists with neuroprotective properties
Enza Lacivita,
University of Bari, Italy

11.40-12.00

OC:  Determination of propofol by fast GC/MS-TOF in three cases of poisoning
Gabriella Roda,
University of Milan, Italy

12.00-13.00

14.00-15.00

POSTER SESSION

13.00-14.00

LUNCH

 

 

Auditorium

NPCF-1

15.00-15.30

KN:  Targeting the cellular prion protein in Alzheimer's diseases
Emiliano Biasini
,
University of Trento, Italy

 

Chair: Emiliano Biasini

15.30-15.50

OC:  Design, synthesis and biological evaluation of new antimetastatic compounds
Elda Meta,
University of  Genoa, Italy

15.50-16.10

OC:  Design and synthesis of new multitarget ligands as useful tools to fight GBM
Simona Sestito,
University of  Pisa, Italy

16.10-16.20

FC:  Oxadiazole Pt(II) complexes STAT3 inhibitors in anticancer therapy
Federica Porta,
University of  Milan, Italy

16.20-16.50

COFFEE BREAK

16.50-17.10

OC:  Cucurbitacins binding to serum albumins from different species: a surface plasmon resonance and circular dichroism study
Edoardo Fabini,
University of Bologna, Italy

17.10-17.20

FC:  New insights in stability of oxybutynin: an example of an integrated chemical and metabolic stability study
Silvio AprileUniversity of Piemonte-Orientale, 
Novara, Italy

17.20-17.30

FC:  1,4-Dihydropyridines active on the SIRT1/AMPK pathway ameliorate skin repair and mitochondrial function and exhibit inhibition of proliferation in cancer cells
Giulia Stazi
University La Sapienza, Rome, Italy

 

 

Trumpet

NPCF-2

15.00-15.30

KN:  SAR studies on P2X7 antagonists against neuroinflammation
Paolo Pevarello
,
Axxam, Milan, Italy

 

Chair:  Paolo Pevarello

15.30-15.50

OC:  2’,3’-Substituted ATP derivatives as nanomolar antagonists of the purinergic P2X3 receptors and potential analgesic agents
Ajiroghene Thomas
,
University of Camerino, Italy

15.50-16.10

OC:  Substituted thiadiazines with the anti-stress action as a promising cardiovascular drugs
Alexey Sarapultsev,
Ural Branch of the RAS, Ekaterinburg, Russia

16.10-16.20

FC:  A new LP1 analogue is used to better understand MOR ligand binding domain and its mechanisms of activation
Simone Ronsisvalle, University of  Catania, Italy

16.20-16.50

COFFEE BREAK

16.50-17.10

OC:  Monothiocarbamates strongly inhibit carbonic anhydrases in vitro and possess intraocular pressure lowering activity in an animal model of glaucoma
Fabrizio Carta,
University of Florence, Italy

17.10-17.20

FC:  Evaluation of a curcumin-based analogue as potential multifunctional compound for the treatment of Alzheimer’s disease
Federica Bisceglia,
University of Pavia, Italy

17.20-17.30

FC:  Silkworm pupae as a new source of high value edible proteins?
Alessandra Altomare,
University of Milan, Italy

18.00

   DCF-SCI GENERAL MEETING ( ASSEMBLEA DELLA DIVISIONE DI      CHIMICA FARMACEUTICA)

22.00

AFTER DINNER MUSIC PARTY - Caffè 100deici

 

 

 

 

Tuesday 13th September 2016 – Hotel Giò

 

 

Auditorium

 

 

Chair: Violetta Cecchetti

8.30-9.20

PL: Antivirals, a lot has been achieved, yet a long way to go?
Johan Neyts, Catholic University of Leuven (KU Leuven), Belgium

 

  

Auditorium

NMMC-3

 

Chairs: Violetta Cecchetti and Federico Corelli

9.30-10.00

KN:  Inhibition of carbonic anhydrases from pathogens: underexplored antiinfective targets
Claudiu Supuran
,
University of Florence, Italy

10.00-10.20

OC:  Human DDX3 protein: a new valuable target to develop broad spectrum antiviral agents
Annalaura Brai, University of Siena, Italy

10.20-10.40

OC:  Allosteric inhibitors against HIV-1 integrase: computational and synthetic approaches for developing lavendustin B analogues
Laura De Luca,
University of  Messina, Italy

10.40-11.00

COFFEE BREAK

11.00-11.20

OC:  Modified doxorubicins: "gaseous approach" to overcome cardiotoxicity and multidrug resistance
Kostantin Chegaev,
University of Turin, Italy

11.20-11.40

OC:  Structure-based polypharmacology in drug design
Giulio Rastelli,
University of Modena-Reggio Emilia, Italy

11.40-12.00

OC: Discovery and optimization of novel inhibitors for the ether lipid-generating enzyme AGPS as anticancer agents
Roberta MazzoneUniversity La Sapienza, Rome, Italy

 

  

Trumpet

NMMC-4

 

Chairs: Ersilia De Lorenzi and Tiziano Bandiera

9.30-10.00

KN: MuTaLig: a COST Action to speed up the drug discovery process  by means of the multi-targeting paradigm
Stefano Alcaro
, Magna Graecia University, Catanzaro, Italy

10.00-10.20

OC: Scaled molecular dynamics simulations for residence time-based prioritiziation of drug-like compounds
Sergio Decherchi, BiKi-IIT, Genoa, Italy

10.20-10.40

OC: Some like it hot: biomolecule analytics using microscale thermophoresis
Francesca Viganò,
NanoTemper Technologies GmbH, Germany

10.40-11.00

COFFEE BREAK

11.00-11.20

OC: Structure-guided design of novel isoxazole and benzimidazole derivatives as potent 5-Lipoxygenase (5-LO) and 5-LO Activating Protein (FLAP) inhibitors
Abdurrahman Olğaç, Gazi University, Etiler, Ankara, Turkey

11.20-11.40

OC:  Design and synthesis of polycationic nucleopeptides as attractive tools for microrna functional modulation
Stefano Tomassi,
 Federico II University, Naples, Italy

11.40-12.00

OC:  Metabolomics for nutraceutical research: new insights into cranberry activity against uropathogenic E. coli
Stefano Dall’Acqua,
University of Padua, Italy

12.00-13.00
14.00-15.00

POSTER SESSION

13.00-14.00

LUNCH

 

 

Auditorium

NPCF-3

15.00-15.30

KN:  Drug design, synthesis and biological evaluation of antiretroviral and anticancer agents
Valeria Famiglini
,
University La Sapienza, Rome, Italy

 

Chair: Valeria Famiglini

15.30-15.50

OC: Structure activity relationship of novel antimicrobial agents, acting as inhibitors of the bacterial cell division protein FTSZ
Valentina Straniero,
University of  Milan, Italy

15.50-16.10

OC:  New insights into the interaction between pyrrolyl diketoacids and HIV-1 integrase active site
Valentina Noemi Madia,
 University La Sapienza, Rome, Italy

16.10-16.20

FC:  Development of a LC-MS method for the identification of inhibitors of the Anopheles gambiae 3-hydroxy-kynurenine transaminase (Ag-HKT)
Rossana Canavesi ,
University of Piemonte Orientale, Novara, Italy

16.20-16.50

COFFEE BREAK

16.50-17.10

OC:  Rational design of antitubercolar 2-aminothiazoles
Elisa Azzali,
University of Parma, Italy

17.10-17.30

OC:  New pyrazole compounds as valuable pre-clinical candidates for TB treatment
Giulia Venditti, University of La Sapienza, Rome, Italy

17.30-17.40

FC:  Total synthesis of sambubiose [β-D-xylopyranosyl-(1->2)-β-D-glucopyranose]
Maria Gessica Ciulla, U
niversity of Urbino, Italy

17.40-17.50

 

FC:  Carboxylic acid derivatives of pyrazolo[1,5-a]pyrimidine: the first example of aldose reductase differential inhibitors (ARDIs)  
Luca Quattrini, U
niversity of Pisa, Italy

 

Trumpet

NPCF-4

15.00-15.30

 

KN:  Synthesis and biological evaluation of 1,5-diphenylpyrrole derivatives as COX-2 selective inhibitors and NO-releasing agents and development of a novel BRD9 chemical probe
Sara Consalvi
,
University La Sapienza, Rome, Italy

Chair:  Sara Consalvi

15.30-15.50

OC:  Inflammasomes and covalent drugs:another step towards direct NLRP3 inhibition
Mattia Cocco
,
University of Turin, Italy

15.50-16.10

OC:  Design, synthesis and antiproliferative activity of pyrido-pyrrolizines, new tripentone analogues
Barbara Parrino,
University of Palermo, Italy

16.10-16.20

FC:  Potent and selective P-gp modulators for altering multidrug resistance due to pump overexpression
Stefano Guglielmo, University of Turin, Italy

16.20-16.50

COFFEE BREAK

16.50-17.10

OC:  A fragment-based approach to target protein-protein interactions in the Fanconi anemia pathway
Francesca Morreale,
University of Dundee, United Kingdom

17.10-17.30

OC:  Structural requirements of the antiproliferative activity of biphenyl nicotinamides
Maria Majellaro,
University of Bari, Italy

17.30-17.40

FC:  Identification of new inhibitors of PRMTs by a multi-substrate-adduct approach 
Ciro Milite,
University of Salerno, Italy

17.40-17.50

FC:   Discovering the hidden chemical space of chemistry reactions: from 1,2,3-triazoles  nucleus to Zinclick galaxy            
Alberto Massarotti,
University of Piemonte Orientale, Novara, Italy

18.00

ROUND TABLE -  Evoluzione delle competenze professionali del Farmacista alla luce del nuovo piano di studi nazionale del Corso di Laura Magistrale in Farmacia

20.30

SOCIAL DINNER - Hotel Giò

 

 

 

 

Wednesday 14th September 2016 – Hotel Giò

 

  

Auditorium

 

 

Chair: Benedetto Natalini

9.00-9.50

PLRole of FXR-FGF19 in the gut liver axis: relevance in metabolic disease and cancer
Antonio Moschetta, University of Bari, Italy

 

 

Auditorium

NMMC-5

 

Chairs: Benedetto Natalini and Roberto Di Santo

10.00-10.30

KN: The analytical armamentarium for the study of new semi- synthetic glycoconjugates as potential neo-glycovaccines against tubercolisis
Gabriella Massolini
,
University of Pavia, Italy

10.30-10.50

OC: Pyridobenzothiazoles efficiently inhibit flavivirus replication in cells: combining structural biology and virology studies to investigate the mechanism of action
Giuseppe Manfroni, University of Perugia, Italy

10.50-11.10

OC: Identification of “preferred” human kinase inhibitors for human african trypanosomiasis through a statistical analysis-driven approach
Emanuele Amata,
University of Catania and Northeastern University, Boston, United States

11.10-11.30

COFFEE BREAK

11.30-11.50

OC: Heme oxygenase-1 inhibition: a novel strategy for the design of azole-based antitumor agents
Valeria Pittalà,
University of Catania, Italy

11.50-12.10

OC: Targeting kinases with 4-anilinopyrimidines: from hit to lead and future perspectives
Giovanni Marzaro,
University of Padua, Italy

 

 

Trumpet

NMMC-6

 

Chairs: Federico Da Settimo and Cosimo Damiano Altomare

10.00-10.30

KN: Bridging pharmaceutical chemistry and drug targeting to investigate the role of the translocator protein TSPO 18kD
Nunzio Denora
,
University of Bari, Italy

10.30-10.50

OC: Translocator Protein (TSPO) ligand residence time: a new parameter to predict neurosteroidogenic efficacy for N,N-dialkyl-2-arylindol-3-ylglyoxylamides (PIGAs)
Sabrina Taliani, University of Pisa, Italy

10.50-11.10

OC: Inverse agonist properties of the A2A adenosine receptor ligands.
Gabriella Marucci,
University of Camerino, Italy

11.10-11.30

COFFEE BREAK

11.30-11.50

OC: Role of mobile phase composition in the chromatographic enantioseparation of pharmaceutically relevant compounds with low- and high-molecular weight chiral selectors
Roccaldo Sardella, University of Perugia, Italy

11.50-12.10

OC: Optimization  of  coumarin-based  multitarget ligands: discovery of potent water-soluble and brain-permeant neuroprotective AChE-MAO B inhibitors
Leonardo Pisani, University of Bari, Italy

 

 

Auditorium

 

 

Chair: Roberto Pellicciari

12.10-13.10

TES Pharma sponsored CLCrossing over: a drug discovery perspective from Pharma and Academia 

Magid Abou-Gharbia, Temple University, USA

13.10-13.30

POSTER PRIZEand CLOSING REMARKS 

13.30

LUNCH

 

 

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